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I think we have all heard this story before, but David Shore discusses Robert Sean Leonard's audition for House in this interview. It's quite interesting what he says about Wilson having to be a complicated character for House to be interested in him!
http://www.cbc.ca/radio/q/david-shore-on-what-tv-gets-wrong-about-male-friendships-1.3043808?autoplay=true
(The bit about RSL starts at 4:20)
http://www.cbc.ca/radio/q/david-shore-on-what-tv-gets-wrong-about-male-friendships-1.3043808?autoplay=true
(The bit about RSL starts at 4:20)